Trifluoroacetic acid → (R)-5-methyl-4-(piperidin-4-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

HRID 340143ノート

反応式

HRID 340143 の反応式
C(O)(C(F)(F)F)=O.[CH3:8][C@H:9]1[C:17]2[C:16]([CH:18]3[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]3)=[N:15][CH:14]=[N:13][C:12]=2[CH2:11][CH2:10]1>C(Cl)Cl>[CH3:8][C@H:9]1[C:17]2[C:16]([CH:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)=[N:15][CH:14]=[N:13][C:12]=2[CH2:11][CH2:10]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 67436185(R)-tert-butyl 4-(5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperidine-1-carboxylate

生成物 1

HCID 67438320(R)-5-methyl-4-(piperidin-4-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

TFA (193 μL, 2.50 mmol) was added to a solution of (R)-tert-butyl 4-(5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperidine-1-carboxylate (32 mg, 0.10 mmol) in DCM (1 mL). The mixture was stirred at room temperature for 1 hour and concentrated to give (R)-5-methyl-4-(piperidin-4-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine as an oil, which was used further without purification.

後処理

  1. concentrationconcentrated

出典と根拠

ORDレコード
ord-18f049d2a0b847528dfb15cb79d99b7a
出典データセット
uspto-grants-2014_11
特許番号
US08895566B2

反応ノート

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