Thionyl Chloride → HCID 86652358、化合物

HRID 340334ノート

反応式

HRID 340334 の反応式
[NH2:1][C:2]1[C:11]2[N:10]=[CH:9][C:8]([CH2:12][CH2:13][C:14]3[CH:22]=[CH:21][C:17]([C:18](O)=[O:19])=[CH:16][C:15]=3[CH3:23])=[CH:7][C:6]=2[C:5]2[CH:24]=[CH:25][C:26]([CH3:28])=[CH:27][C:4]=2[N:3]=1.S(Cl)([Cl:31])=O>>[NH2:1][C:2]1[C:11]2[N:10]=[CH:9][C:8]([CH2:12][CH2:13][C:14]3[CH:22]=[CH:21][C:17]([C:18]([Cl:31])=[O:19])=[CH:16][C:15]=3[CH3:23])=[CH:7][C:6]=2[C:5]2[CH:24]=[CH:25][C:26]([CH3:28])=[CH:27][C:4]=2[N:3]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 58213539HCID 58213539、化合物

生成物 1

HCID 86652358HCID 86652358、化合物

実験手順

A solution of 4-(2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl)-3-methylbenzoic acid (from the previous step) in thionyl chloride was stirred at 60° C. for 3 hour. After cooling to ambient temperature, the reaction mixture was concentrated en vacuo. The crude material was used for next step without purification.

後処理

  1. concentrationthe reaction mixture was concentrated en vacuo
  2. customThe crude material was used for next step without purification

出典と根拠

ORDレコード
ord-611b483cfb9e44098db8337c0b78f391
出典データセット
uspto-grants-2014_11
特許番号
US08895577B2

反応ノート

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