Hydrochloric Acid → HCID 59797049、化合物

HRID 34043ノート

反応式

HRID 34043 の反応式
[CH3:1][O:2][C:3]1[C:11]([C:12](N)=[O:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[C:5](/[CH:15]=[CH:16]/[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[N:6][NH:7]2.[OH-:23].[Li+].Cl>>[CH3:1][O:2][C:3]1[C:11]([C:12]([OH:23])=[O:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[C:5](/[CH:15]=[CH:16]/[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[N:6][NH:7]2

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 59797368HCID 59797368、化合物

生成物 1

HCID 59797049HCID 59797049、化合物

反応条件

温度
110 °C

実験手順

22 mg of 4-methoxy-3-(E)-styryl-1H-indazole-5-carboxylic acid amide was added to 3 mL of 4N lithium hydroxide aqueous solution, and stirred at 110° C. for 4 hours. After cooling on ice, the reaction solution was neutralized with 2N hydrochloric acid under ice cooling, and the precipitated crystals were collected by filtration and washed with water. This was then dried under reduced pressure, to afford 20 mg of the title compound as brown crude crystals.

後処理

  1. temperatureAfter cooling on ice
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with water
  4. customThis was then dried under reduced pressure

出典と根拠

ORDレコード
ord-68273f5260b9449c8cffa603ab0d3dfb
出典データセット
uspto-grants-2008_09
特許番号
US07429609B2

反応ノート

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