HCID 4183387、化合物 → 5-Methyl-6-(4-morpholinyl)-3-pyridinamine

HRID 340460ノート

反応式

HRID 340460 の反応式
[CH3:1][C:2]1[C:3]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[N:4][CH:5]=[C:6]([N+:8]([O-])=O)[CH:7]=1>[Pd].CO>[CH3:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[N:4][C:3]=1[N:11]1[CH2:12][CH2:13][O:14][CH2:15][CH2:16]1

参加物

4

反応物 1

HCID 4183387HCID 4183387、化合物

生成物 1

HCID 592764965-Methyl-6-(4-morpholinyl)-3-pyridinamine収率 90.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A methanol (20 ml) solution containing 4-(3-methyl-5-nitropyridin-2-yl)morpholine (67 mg) was prepared and subjected to a hydrogenation reaction (room temperature; 1 bar; flow rate: 1 ml/min; 10% Pd/C) using H-cube™. Then, the solvent was distilled away under reduced pressure, and a purple solid of 5-methyl-6-morpholinopyridin-3-amine (52.4 mg) was thus obtained.

後処理

  1. customwas prepared
  2. distillationThen, the solvent was distilled away under reduced pressure

出典と根拠

ORDレコード
ord-0f62bd68746b4517a2f18575881d5b08
出典データセット
uspto-grants-2014_11
特許番号
US08895585B2

反応ノート

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