Dimethylformamide dimethyl acetal → 1-(5-Bromopyridin-3-yl)-3-(dimethylamino)prop-2-ene-1-one
反応式
CO[CH:3](OC)[N:4]([CH3:6])[CH3:5].[Br:9][C:10]1[CH:11]=[C:12]([C:16](=[O:18])[CH3:17])[CH:13]=[N:14][CH:15]=1>>[Br:9][C:10]1[CH:11]=[C:12]([C:16](=[O:18])[CH:17]=[CH:3][N:4]([CH3:5])[CH3:6])[CH:13]=[N:14][CH:15]=1参加物
3
反応条件
- 温度
- 100 °C
実験手順
An N,N-dimethylformamide dimethylacetal (2 ml) solution containing 1-(5-bromopyridin-3-yl)ethanone (100 mg) (WO2009/87224 A1) was stirred at 100° C. for 5 hours. The solvent was distilled away under reduced pressure, and a yellow solid of 1-(5-bromopyridin-3-yl)-3-(dimethylamino)prop-2-ene-1-one was thus obtained.
後処理
- distillationThe solvent was distilled away under reduced pressure
出典と根拠
- ORDレコード
- ord-9ea3052c2c8641589f76c41843130f54
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08895585B2
反応ノート
読み込み中…