7-nitro-3-(1H-pyrazol-1-yl)quinoline → 3-(1H-pyrazol-1-yl)quinolin-7-amine

HRID 340474ノート

反応式

HRID 340474 の反応式
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[C:9]([N:14]3[CH:18]=[CH:17][CH:16]=[N:15]3)[CH:10]=[N:11]2)=[CH:6][CH:5]=1)([O-])=O>[Pd].CO>[N:14]1([C:9]2[CH:10]=[N:11][C:12]3[C:7]([CH:8]=2)=[CH:6][CH:5]=[C:4]([NH2:1])[CH:13]=3)[CH:18]=[CH:17][CH:16]=[N:15]1

参加物

4

反応物 1

HCID 686188247-nitro-3-(1H-pyrazol-1-yl)quinoline

生成物 1

HCID 866838633-(1H-pyrazol-1-yl)quinolin-7-amine収率 63.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A methanol (10 ml) solution containing 7-nitro-3-(1H-pyrazol-1-yl)quinoline (36 mg) was prepared and subjected to a hydrogenation reaction (80° C.; 50 bar; flow rate: 1 ml/min; 10% Pd/C) using H-cube™. Thereafter, the solvent was distilled away under reduced pressure, and a purple solid of 3-(1H-pyrazol-1-yl)quinolin-7-amine (20 mg) was thus obtained.

後処理

  1. customwas prepared
  2. distillationThereafter, the solvent was distilled away under reduced pressure

出典と根拠

ORDレコード
ord-0ea0fd17a6bc4c6eb3e0e5ff5de7e47a
出典データセット
uspto-grants-2014_11
特許番号
US08895585B2

反応ノート

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