Dimethylformamide → propargyl N-methoxy-2,4-dichlorobenzimidate
反応式
[CH3:1][O:2][NH:3][C:4](=[O:13])[C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:6]=1[Cl:12].C(=O)([O-])[O-].[K+].[K+].[CH2:20](Br)[C:21]#[CH:22].CN(C)C=O>O>[CH3:1][O:2][N:3]=[C:4]([O:13][CH2:22][C:21]#[CH:20])[C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:6]=1[Cl:12]参加物
6
実験手順
1.0 g of N-methoxy-2,4-dichlorobenzamide, 0.75 g of potassium carbonate and 0.65 g of propargyl bromide were added to 10 ml of N,N-dimethylformamide, and the mixture was stirred for 3 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated and purified by silica gel column chromatography to obtain 0.35 g of propargyl N-methoxy-2,4-dichlorobenzimidate.
後処理
- additionwas added to the reaction solution
- extractionthe mixture was extracted with ethyl acetate
- customThe extract was dried
- concentrationconcentrated
- custompurified by silica gel column chromatography
出典と根拠
- ORDレコード
- ord-bc47ddbc82764811b755545cf676a4fc
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05733935
反応ノート
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