Diiodomethane → 2-Iodo-4-methyl-5-nitropyridine
反応式
N[C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1.S([O-])(OCCC(C)C)=O.[I:21]CI>>[I:21][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
To a solution of 1.0 g of 2-amino-4-methyl-5-nitropyridine in 10 mL of diiodomethane was added 1.8 mL of isopentyl sulfite at room temperature, stirred at this temperature for 30 minutes, and after raising the temperature to 80° C., the solution was stirred for 2 hours. The diiodomethane was evaporated, and the crude product was purified and separated by silica gel column chromatography (ethyl acetate:n-hexane=1:20), to afford 897 mg of the title compound as colorless crystals.
後処理
- stirringthe solution was stirred for 2 hours
- customThe diiodomethane was evaporated
- customthe crude product was purified
- customseparated by silica gel column chromatography (ethyl acetate:n-hexane=1:20)
出典と根拠
- ORDレコード
- ord-4591426222324116a52532a1d4076497
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07429609B2
反応ノート
読み込み中…