Nitric Acid → 4-Bromo-7-hydroxy-6-nitro-2,3-dihydro-1H-inden-1-one
反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:12].C(OC(=O)C)(=O)C.[N+:20]([O-])([OH:22])=[O:21]>C(O)(=O)C>[Br:1][C:2]1[CH:10]=[C:9]([N+:20]([O-:22])=[O:21])[C:8]([OH:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:12]参加物
5
実験手順
4-Bromo-7-hydroxyindan-1-one (3.06 g, 13.5 mmol) was suspended in acetic acid (20 mL), and acetic anhydride (1.66 mL, 17.6 mmol) and fuming nitric acid (838 μL, 20.2 mmol) dissolved in acetic acid (10 mL) were added. The mixture was stirred at room temperature for 3 hr. The solvent was evaporated under reduced pressure and the precipitated yellow crystals were collected by filtration to give the title compound (2.98 g, yield 79%).
後処理
- additionwere added
- customThe solvent was evaporated under reduced pressure
- filtrationthe precipitated yellow crystals were collected by filtration
出典と根拠
- ORDレコード
- ord-1124d3474cab404aa625d5fbd57a2ec6
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08895591B2
反応ノート
読み込み中…