Hydrochloric Acid → 1H-thieno[2,3-c]pyrazole-5-carbonitrile

HRID 34075

反応式

HRID 34075 の反応式
C([N:4]1[C:8]2[S:9][C:10]([C:12]#[N:13])=[CH:11][C:7]=2[CH:6]=[N:5]1)(=O)C.Cl>C(O)C.[OH-].[Na+]>[NH:4]1[C:8]2[S:9][C:10]([C:12]#[N:13])=[CH:11][C:7]=2[CH:6]=[N:5]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 689272371-Acetyl-1H-thieno[2,3-c]pyrazole-5-carbonitrile

生成物 1

HCID 689269941H-thieno[2,3-c]pyrazole-5-carbonitrile収率 100.2%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

To a suspension of 215 mg of 1-acetyl-1H-thieno[2,3-c]pyrazole-5-carbonitrile in 8 mL of ethanol, 1 mL of 5N sodium hydroxide aqueous solution was added at room temperature, and stirred at this temperature for 10 minutes. Then the solution was neutralized with 5N hydrochloric acid, extracted with ethyl acetate, and the organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated, to afford 168 mg of the title compound as colorless crystals.

後処理

  1. additionwas added at room temperature
  2. extractionextracted with ethyl acetate
  3. washthe organic layer was washed with saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-fe2c8efc4b0447988675b250e4cc7df3
出典データセット
uspto-grants-2008_09
特許番号
US07429609B2

関連ノート

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