Hydrochloric Acid → 1H-thieno[2,3-c]pyrazole-5-carbonitrile
反応式
C([N:4]1[C:8]2[S:9][C:10]([C:12]#[N:13])=[CH:11][C:7]=2[CH:6]=[N:5]1)(=O)C.Cl>C(O)C.[OH-].[Na+]>[NH:4]1[C:8]2[S:9][C:10]([C:12]#[N:13])=[CH:11][C:7]=2[CH:6]=[N:5]1参加物
5
実験手順
To a suspension of 215 mg of 1-acetyl-1H-thieno[2,3-c]pyrazole-5-carbonitrile in 8 mL of ethanol, 1 mL of 5N sodium hydroxide aqueous solution was added at room temperature, and stirred at this temperature for 10 minutes. Then the solution was neutralized with 5N hydrochloric acid, extracted with ethyl acetate, and the organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated, to afford 168 mg of the title compound as colorless crystals.
後処理
- additionwas added at room temperature
- extractionextracted with ethyl acetate
- washthe organic layer was washed with saturated brine
- dry with materialdried over anhydrous magnesium sulfate
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-fe2c8efc4b0447988675b250e4cc7df3
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07429609B2
反応ノート
読み込み中…