Ethanone, 1-(1H-pyrazolo[4,3-c]pyridin-1-yl)- → 1H-Pyrazolo[4,3-c]pyridine

HRID 34082ノート

反応式

HRID 34082 の反応式
[N:1]1(C(=O)C)[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[N:2]1>C(O)C.[OH-].[Na+]>[NH:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[N:2]1

参加物

4

反応物 1

HCID 23070130Ethanone, 1-(1H-pyrazolo[4,3-c]pyridin-1-yl)-

生成物 1

HCID 199305001H-Pyrazolo[4,3-c]pyridine収率 81.5%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

To a solution of 6.44 g of 1-pyrazolo[4,3-c]pyridin-1-yl-ethanone in 120 mL of ethanol, 10 mL of 5N sodium hydroxide aqueous solution was added at room temperature and stirred at this temperature for 30 minutes. After neutralization with 5N hydrochloric acid, the solvent was evaporated, the residue was washed with ethyl acetate, and the solvent of filtrate was evaporated, to afford 3.88 g of the title compound as pale yellow crystals.

後処理

  1. customAfter neutralization with 5N hydrochloric acid, the solvent was evaporated
  2. washthe residue was washed with ethyl acetate
  3. customthe solvent of filtrate was evaporated

出典と根拠

ORDレコード
ord-bc9584153d024b7d907f9748370ecf08
出典データセット
uspto-grants-2008_09
特許番号
US07429609B2

反応ノート

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