Benzoyl Peroxide → 1-(Bromomethyl)-2-fluoro-4-iodobenzene

HRID 341038

反応式

HRID 341038 の反応式
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[CH3:9].[Br:10]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:10][CH2:9][C:3]1[CH:4]=[CH:5][C:6]([I:8])=[CH:7][C:2]=1[F:1]

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 1234922-Fluoro-4-iodotoluene

生成物 1

HCID 222404061-(Bromomethyl)-2-fluoro-4-iodobenzene

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

2-Fluoro-4-iodo-1-methylbenzene (2.0 g, 8.6 mmol) was dissovled in carbon tetrachloride (10 mL), treated with N-bromosuccinimide (1.5 g, 8.6 mmol, 1 equiv) and benzoyl peroxide (9.0 mg, 0.004 equiv) and placed into an oil bath preheated to 80° C. for 3 hours. The mixture was cooled to ambient temperature, filtered and the filtrate was concentrated in vacuo, providing the titled compound.

後処理

  1. customplaced into an oil bath
  2. filtrationfiltered
  3. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-6317748c3b054fe5b1ecf65ca3bcedde
出典データセット
uspto-grants-2014_11
特許番号
US08895580B2

関連ノート

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