Thionyl Chloride → 5-Bromo-3-fluoropyridine-2-carbonyl chloride
反応式
[Br:1][C:2]1[CH:3]=[C:4]([F:11])[C:5]([C:8](O)=[O:9])=[N:6][CH:7]=1.S(Cl)([Cl:14])=O>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]([F:11])[C:5]([C:8]([Cl:14])=[O:9])=[N:6][CH:7]=1参加物
4
実験手順
5-Bromo-3-fluoropyridine-2-carboxylic acid (0.40 g, 1.8 mmol) was dissolved in dichloromethane (8 mL), treated with thionyl chloride (0.80 mL, 11 mmol, 6 equiv) and the mixture was placed into a preheated oil bath at 45° C. for 3 hours. The mixture was concentrated in vacuo, providing the titled compound.
後処理
- concentrationThe mixture was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-a6b4a0336c6f4443a596bf37f355a251
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08895580B2
反応ノート
読み込み中…