Sodium Carbonate → 1-BOC-4-(4-bromophenoxy)piperidine

HRID 341168

反応式

HRID 341168 の反応式
[Br:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[CH:4][CH:3]=1.C([O-])([O-])=O.[Na+].[Na+].[O:21](C(OC(C)(C)C)=O)[C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=O>O1CCOCC1.O>[C:25]([O:24][C:22]([N:10]1[CH2:9][CH2:8][CH:7]([O:6][C:5]2[CH:13]=[CH:14][C:2]([Br:1])=[CH:3][CH:4]=2)[CH2:12][CH2:11]1)=[O:21])([CH3:28])([CH3:27])[CH3:26]

参加物

6

反応物 3

HCID 10340Sodium CarbonateHCID 90495Di-tert-butyl dicarbonateHCID 126455664-(4-Bromophenoxy)piperidine

生成物 1

HCID 467390061-BOC-4-(4-bromophenoxy)piperidine収率 86.4%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

To a solution of 4-(4-Bromo-phenoxy)-piperidine (1 g, 3.9 mmol) in dioxane (20 ml), water (20 ml) added Na2CO3 (1.6 g, 18.9 mmol) and (BOC)2O (1.3 g, 5.9 mmol). Reaction stirred at ambient for 48 hours, solvent was removed under reduced pressure and residue partitioned between EtOAc and water the layers were separated. The organic layer was washed with brine, dried (MgSO4), and concentrated under reduced pressure to give (1.2 g) of product.

後処理

  1. customReaction
  2. customsolvent was removed under reduced pressure and residue
  3. custompartitioned between EtOAc and water the layers
  4. customwere separated
  5. washThe organic layer was washed with brine
  6. dry with materialdried (MgSO4)
  7. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-c093a24d27e94e44a89572729fb84f14
出典データセット
uspto-grants-2014_11
特許番号
US08895745B2

関連ノート

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