1-Amino-3-(morpholin-4-yl)propan-2-ol → 3-[(E)-2-(4-fluorophenyl)ethenyl]-N-(2-hydroxy-3-morpholin-4-ylpropyl)-4-methoxy-1H-indazole-5-carboxamide

HRID 34117

反応式

HRID 34117 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:21](O)=[O:22])[C:17]=3[O:19][CH3:20])[NH:12][N:11]=2)=[CH:4][CH:3]=1.[NH2:24][CH2:25][CH:26]([OH:34])[CH2:27][N:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>>[OH:34][CH:26]([CH2:27][N:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1)[CH2:25][NH:24][C:21]([C:16]1[C:17]([O:19][CH3:20])=[C:18]2[C:13](=[CH:14][CH:15]=1)[NH:12][N:11]=[C:10]2/[CH:9]=[CH:8]/[C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1)=[O:22]

参加物

3

反応物 2

HCID 28322311-Amino-3-(morpholin-4-yl)propan-2-olHCID 597972433-[(E)-2-(4-fluorophenyl)-vinyl]-4-methoxy-1H-indazole-5-carboxylic acid

生成物 1

HCID 600348613-[(E)-2-(4-fluorophenyl)ethenyl]-N-(2-hydroxy-3-morpholin-4-ylpropyl)-4-methoxy-1H-indazole-5-carboxamide収率 45.4%

実験手順

100 mg of 3-[(E)-2-(4-fluorophenyl)-vinyl]-4-methoxy-1H-indazole-5-carboxylic acid obtained by Example 234 and 130 mg of 1-amino-3-(morpholine-4-yl)propane-2-ol were condensed in the similar method as described in Example 44, to afford 66 mg of the title compound as colorless needle crystals.

後処理

  1. customcondensed in the similar method

出典と根拠

ORDレコード
ord-cdbb4289407b462dab29ea96153df71a
出典データセット
uspto-grants-2008_09
特許番号
US07429609B2

関連ノート

読み込み中…