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1-Amino-3-(morpholin-4-yl)propan-2-ol → 3-[(E)-2-(4-fluorophenyl)ethenyl]-N-(2-hydroxy-3-morpholin-4-ylpropyl)-4-methoxy-1H-indazole-5-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Amino-3-(morpholin-4-yl)propan-2-ol | HCID 2832231 | — |
| 反応物 | 3-[(E)-2-(4-fluorophenyl)-vinyl]-4-methoxy-1H-indazole-5-carboxylic acid | HCID 59797243 | — |
| 生成物 | 3-[(E)-2-(4-fluorophenyl)ethenyl]-N-(2-hydroxy-3-morpholin-4-ylpropyl)-4-methoxy-1H-indazole-5-carboxamide | HCID 60034861 | 45.4% |
反応手順
100 mg of 3-[(E)-2-(4-fluorophenyl)-vinyl]-4-methoxy-1H-indazole-5-carboxylic acid obtained by Example 234 and 130 mg of 1-amino-3-(morpholine-4-yl)propane-2-ol were condensed in the similar method as described in Example 44, to afford 66 mg of the title compound as colorless needle crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07429609B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-cdbb4289407b462dab29ea96153df71a |
| 出典メモ | uspto-grants-2008_09 |