Morpholine → Acetic Acid 5-(morpholin-4-yl)methyl-furan-2-ylmethyl Ester

HRID 34118

反応式

HRID 34118 の反応式
[C:1]([O:4][CH2:5][C:6]1[O:10][C:9]([CH:11]=O)=[CH:8][CH:7]=1)(=[O:3])[CH3:2].[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>ClCCCl.ClCCl>[N:13]1([CH2:11][C:9]2[O:10][C:6]([CH2:5][O:4][C:1](=[O:3])[CH3:2])=[CH:7][CH:8]=2)[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1

参加物

6

反応物 3

HCID 8083MorpholineHCID 663495-Acetoxymethyl-2-furaldehydeHCID 5049666Sodium triacetoxyborohydride

生成物 1

HCID 14568660Acetic Acid 5-(morpholin-4-yl)methyl-furan-2-ylmethyl Ester

試薬・触媒・溶媒 2

HCID 111,2-Dichloroethane溶媒HCID 6344Dichloromethane溶媒

実験手順

Under nitrogen atmosphere, to a solution of 2.0 g of 5-acetoxymethyl-2-furanaldehyde and 1.1 mL of morpholine in 35 mL of 1,2-dichloroethane was added 4.0 g of sodium triacetoxy borohydride at room temperature, and stirred at this temperature for 3 hours. The reaction solution was diluted with dichloromethane, washed successively with saturated aqueous sodium hydrogen carbonate and saturated brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated, and the residue was purified and separated by silica gel column chromatography, to afford 2.3 g of the title compound as a colorless oil.

後処理

  1. washwashed successively with saturated aqueous sodium hydrogen carbonate and saturated brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customThe solvent was evaporated
  4. customthe residue was purified
  5. customseparated by silica gel column chromatography

出典と根拠

ORDレコード
ord-c408746cbab8470790f98487d756d10d
出典データセット
uspto-grants-2008_09
特許番号
US07429609B2

関連ノート

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