Hydrochloric Acid → HCID 25154341、化合物

HRID 341279ノート

反応式

HRID 341279 の反応式
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:22])[NH:12][C:13]1[S:14][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:16][N:17]=1)(=O)C.Cl>C1COCC1>[OH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]([NH:12][C:13]1[S:14][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:16][N:17]=1)=[O:22]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 251886012-(Acetyloxy)-N-[5-(methylsulfonyl)-2-thiazolyl]benzamide

生成物 1

HCID 25154341HCID 25154341、化合物収率 95.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 7 (1.0 g, 2.94 mmol, 1.0 eq) dissolved in THF (20 mL) was added under stirring to 2M HCl (100 mL). The reaction was refluxed for one hour and allowed to cool under stirring over one hour. The product was filtered using a sintered glass funnel, washed with distilled water and THF and dried in high vacuum to afford 834 mg (95%) of 6 as a colorless solid.

後処理

  1. additionwas added
  2. temperatureThe reaction was refluxed for one hour
  3. temperatureto cool
  4. filtrationThe product was filtered
  5. washwashed with distilled water and THF
  6. customdried in high vacuum

出典と根拠

ORDレコード
ord-49b46472342d45449dddfb46848fa93f
出典データセット
uspto-grants-2014_11
特許番号
US08895752B2

反応ノート

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