Water → 3-Azidopiperidin-2-one

HRID 34135ノート

反応式

HRID 34135 の反応式
Br[CH:2]1[CH2:7][CH2:6][CH2:5][NH:4][C:3]1=[O:8].[N-:9]=[N+:10]=[N-:11].[Na+].O>CN(C)C=O>[N:9]([CH:2]1[CH2:7][CH2:6][CH2:5][NH:4][C:3]1=[O:8])=[N+:10]=[N-:11]

参加物

5

反応物 3

HCID 962WaterHCID 33557Sodium AzideHCID 1181713-Bromopiperidin-2-one

生成物 1

HCID 230701363-Azidopiperidin-2-one収率 56.5%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

To a solution of 2.0 g of 3-bromopiperidin-2-one in 30 ml of N,N-dimethylformamide was added 5.9 g of sodium azide, followed by stirring at 60° C. overnight. After cooling down to room temperature, water was added to the reaction mixture and then the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give 890 mg of the title compound as a yellow oil.

後処理

  1. temperatureAfter cooling down to room temperature
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with water and saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-4b22bc59313e4936ae5b7c24eb6c20e4
出典データセット
uspto-grants-2008_09
特許番号
US07429609B2

反応ノート

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