Water → 4-Bromo-2-fluoro-3-(trifluoromethyl)aniline

HRID 341737

反応式

HRID 341737 の反応式
[Br:1]N1C(=O)CCC1=O.[F:9][C:10]1[C:16]([C:17]([F:20])([F:19])[F:18])=[CH:15][CH:14]=[CH:13][C:11]=1[NH2:12].O>CN(C)C=O>[Br:1][C:15]1[CH:14]=[CH:13][C:11]([NH2:12])=[C:10]([F:9])[C:16]=1[C:17]([F:18])([F:19])[F:20]

参加物

5

反応物 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 1455693-Amino-2-fluorobenzotrifluoride

生成物 1

HCID 536697144-Bromo-2-fluoro-3-(trifluoromethyl)aniline収率 76.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

A solution of N-bromosuccinimide (24.9 g) in N,N-dimethyl formamide was added to a solution of 2-fluoro-3-trifluoromethylaniline (25 g) in dimethyl formamide. The mixture was stirred for four and a half hours. It was poured into water and the oil was separated. The aqueous layers was extracted with ether and the combined organic layers were washed with water, dried (MgSO4) and filtered. The filtrate was evaporated to dryness and the residue was distilled to give 4-bromo-2-fluoro-3-trifluoromethylaniline (27.44 g) as an orange oil, b.p. 88°-94° C./4 mbar.

後処理

  1. customthe oil was separated
  2. extractionThe aqueous layers was extracted with ether
  3. washthe combined organic layers were washed with water
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. customThe filtrate was evaporated to dryness
  7. distillationthe residue was distilled

出典と根拠

ORDレコード
ord-631dc0120bfa4282a8aa156e9f50f95d
出典データセット
uspto-grants-1999_01
特許番号
US05856274

関連ノート

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