Nitric Acid → 1-(Methylsulfonyl)-3-nitrobenzene

HRID 341752

反応式

HRID 341752 の反応式
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)(=[O:4])=[O:3].[N+:11]([O-])([OH:13])=[O:12].C(=O)(O)[O-].[Na+]>>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([N+:11]([O-:13])=[O:12])[CH:6]=1)(=[O:4])=[O:3]

参加物

4

反応物 3

HCID 944Nitric AcidHCID 18369Methyl phenyl sulfoneHCID 516892Sodium Bicarbonate

生成物 1

HCID 763121-(Methylsulfonyl)-3-nitrobenzene

実験手順

Phenyl methyl sulphone (4.0 g) was added, portionwise, to fuming nitric acid stirred at 0° C. The reaction mixture was allowed to warm to room temperature, stirred for 1 hour, and then poured carefully onto ice. The solution was carefully neutralised with sodium bicarbonate and the mixture filtered at the pump. The solid collected was washed with water and dried under reduced pressure over potassium hydroxide to give the title compound as a white solid (5.63 g) in a sufficient state of purity for the next reaction.

後処理

  1. additionpoured carefully onto ice
  2. filtrationthe mixture filtered at the pump
  3. customThe solid collected
  4. washwas washed with water
  5. dry with materialdried under reduced pressure over potassium hydroxide

出典と根拠

ORDレコード
ord-4f46a697ee1449fb83383b349f6ca7b4
出典データセット
uspto-grants-1999_01
特許番号
US05856273

関連ノート

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