Ammonia → 2-Aminoadenosine

HRID 341912

反応式

HRID 341912 の反応式
[NH3:1].O.[C@@H:3]1([N:12]2[C:22]3[N:21]=[C:19]([NH2:20])[NH:18][C:16](=O)[C:15]=3[N:14]=[CH:13]2)[O:11][C@H:8]([CH2:9][OH:10])[C@@H:6]([OH:7])[C@H:4]1[OH:5].Cl[Si](C)(C)C>O>[NH2:20][C:19]1[N:21]=[C:22]2[C:15]([N:14]=[CH:13][N:12]2[C@@H:3]2[O:11][C@H:8]([CH2:9][OH:10])[C@@H:6]([OH:7])[C@H:4]2[OH:5])=[C:16]([NH2:1])[N:18]=1

参加物

5

反応物 3

HCID 222Ammonia2 回HCID 6397ChlorotrimethylsilaneHCID 135705230Guanosine Hydrate

生成物 1

HCID 722002-Aminoadenosine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

This variation of the procedures of Robins, et al. supra, eliminated the need to utilize liquid ammonia in the reaction mixture since the ammonia molecule is generated in situ from the silazane reagent and the water of hydration of the guanosine hydrate starting material. Further, the use of chlorotrimethylsilane was not necessary nor was it necessary to conduct the reaction under anhydrous conditions, do a preliminary evaporation, or open and re-seal the Parr bomb under a dry nitrogen atmosphere.

後処理

  1. customthe reaction under anhydrous conditions
  2. customa preliminary evaporation
  3. customopen and re-seal the Parr bomb under a dry nitrogen atmosphere

出典と根拠

ORDレコード
ord-1cfcf0f15bc14dd4893523458c58b8b5
出典データセット
uspto-grants-1999_01
特許番号
US05856466

関連ノート

読み込み中…