Thionyl Chloride → Benzisothiazole

HRID 341974

反応式

HRID 341974 の反応式
C[S:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[CH:5]=[N:6]O.S(Cl)(Cl)=O>ClC1C=CC=CC=1>[S:2]1[C:3]2[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=2[CH:5]=[N:6]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 7867572-(Methylthio)benzaldehyde oxime

生成物 1

HCID 9225Benzisothiazole収率 97%

試薬・触媒・溶媒 1

HCID 7964Chlorobenzene溶媒

実験手順

In a 300 ml four-necked flask equipped with a stirrer, a thermometer, and a condenser, 100 g of monochlorobenzene was placed in advance, to which 33.4 g (0.2 mol) of 2-(methylthio)benzaldehyde oxime was added under nitrogen atmosphere. 25.2 g (0.21 mol) Of thionyl chloride was added dropwise thereto while stirring at a temperature of from -10° to -15° C. and allowed to react for 1 hour at the same temperature. After the termination of the reaction, the reaction mixture was heated to room temperature and subjected to distilling off of the solvent and then to distillation under reduced pressure to give 26.2 g of 1,2-benzisothiazole (boiling point: 115° to 116° C./15 mm Hg, melting point: 39° to 40° C.). The yield was 97% to the 2-(methylthio)benzaldehyde oxime.

後処理

  1. customIn a 300 ml four-necked flask equipped with a stirrer
  2. additionwas added under nitrogen atmosphere
  3. customto react for 1 hour at the same temperature
  4. customAfter the termination of the reaction
  5. distillationto distilling off of the solvent
  6. distillationto distillation under reduced pressure

出典と根拠

ORDレコード
ord-fddecf631c5f470b9a841324e888c970
出典データセット
uspto-grants-1999_01
特許番号
US05856504

関連ノート

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