Thionyl Chloride → 3-Chloro-1,2-benzisothiazole

HRID 341977

反応式

HRID 341977 の反応式
C[S:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[CH:5]=[N:6]O.S(Cl)([Cl:14])=O.ClCl>ClC1C=CC=CC=1>[Cl:14][C:5]1[C:4]2[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=2[S:2][N:6]=1

参加物

5

反応物 3

HCID 24386Thionyl ChlorideHCID 24526ChlorineHCID 7867572-(Methylthio)benzaldehyde oxime

生成物 1

HCID 5981903-Chloro-1,2-benzisothiazole収率 97.6%

試薬・触媒・溶媒 1

HCID 7964Chlorobenzene溶媒

実験手順

In a 300 ml four-necked flask equipped with a stirrer, a thermometer, and a condenser, 100 g of monochlorobenzene was placed in advance, to which 33.4 g (0.2 mol) of 2-(methylthio)benzaldehyde oxime was added under nitrogen atmosphere. 25.2 g (0.21 mol) Of thionyl chloride was added dropwise thereto while stirring at a temperature of from -10° to -15° C. and allowed to react for 1 hour at the same temperature. After the termination of the reaction, 15.6 g (0.22 mol) of chlorine was continuously blown into the reaction mixture while stirring at a temperature of from 70° to 80° C. and allowed to react for 1 hour at the same temperature. After the termination of the reaction, the solvent was distilled off to give 33.1 g of 3-chloro-1,2-benzisothiazole.

後処理

  1. customIn a 300 ml four-necked flask equipped with a stirrer
  2. additionwas added under nitrogen atmosphere
  3. customto react for 1 hour at the same temperature
  4. stirringwhile stirring at a temperature of from 70° to 80° C.
  5. customto react for 1 hour at the same temperature
  6. customAfter the termination of the reaction
  7. distillationthe solvent was distilled off

出典と根拠

ORDレコード
ord-1dfa2bcbdb304676baaeaa88fbc76bf1
出典データセット
uspto-grants-1999_01
特許番号
US05856504

関連ノート

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