Methyl benzofuran-7-carboxylate → Benzofuran-7-ylmethanol

HRID 342085ノート

反応式

HRID 342085 の反応式
[O:1]1[C:5]2[C:6]([C:10](OC)=[O:11])=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[O:1]1[C:5]2[C:6]([CH2:10][OH:11])=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1

参加物

4

反応物 2

HCID 14229730Methyl benzofuran-7-carboxylateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 18787422Benzofuran-7-ylmethanol収率 91%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of methyl benzofuran-7-carboxylate (5.34 g, 30 mmol) was added to a suspension of LAH (2.31 g, 61 mmol) in THF and then heated to reflux for 30 min. The reaction was quenched with ethyl acetate and water. The mixture was made acidic with 12N HCl until all the precipitate dissolved. The ethyl acetate layer was separated, washed with water, dried with brine, and concentrated in vacuo to give a yellow oil (4.03 g, 91%).

後処理

  1. temperatureheated
  2. temperatureto reflux for 30 min
  3. customThe reaction was quenched with ethyl acetate and water
  4. dissolutiondissolved
  5. customThe ethyl acetate layer was separated
  6. washwashed with water
  7. dry with materialdried with brine
  8. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-ef5c89c266084ae6b4feaf6821bd683a
出典データセット
uspto-grants-1999_01
特許番号
US05856529

反応ノート

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