Acetamide → Acetaminophen

HRID 342171

反応式

HRID 342171 の反応式
[C:1]1([CH:8]=[CH:7][C:5]([OH:6])=[CH:4][CH:3]=1)O.[C:9]([NH2:12])(=[O:11])[CH3:10]>O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.P.[W].[W].[W].[W].[W].[W].[W].[W].[W].[W].[W].[W]>[C:9]([NH:12][C:1]1[CH:8]=[CH:7][C:5]([OH:6])=[CH:4][CH:3]=1)(=[O:11])[CH3:10]

参加物

4

反応物 2

HCID 178AcetamideHCID 785Hydroquinone

生成物 1

HCID 1983Acetaminophen

試薬・触媒・溶媒 1

HCID 45231312-Wolframophosphoric acid触媒

実験手順

An intimate mixture of hydroquinone (5.5 g), acetamide (3.5 g) and phosphotungstic acid (0.3 g) was placed in a well stoppered stainless steel tube from which air has been displaced with nitrogen. The tube was kept in a temperature controlled oven at 280°-300° C. for 1.5 hrs. The tube was then removed from the oven, cooled, opened, contents extracted with ethyl acetate, crystallized and products analyzed by gas chromatography. Pure standard substances were used for calibration. The products were also analyzed and identified by GC-mass spectroscopy techniques. The conversion of hydroquinone was 95% by wt. and selectivity to N-acetyl para aminophenol was 86%. Pure N-acetyl para aminophenol could be isolated from the products by column chromatography using alumina.

後処理

  1. customThe tube was then removed from the oven
  2. temperaturecooled
  3. extractioncontents extracted with ethyl acetate
  4. customcrystallized

出典と根拠

ORDレコード
ord-0a6d23bd603b4001be9243f7118d11a0
出典データセット
uspto-grants-1999_01
特許番号
US05856575

関連ノート

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