Ethyl Acetate → 1-(4-Bromo-phenyl)-isoquinolin-6-ol

HRID 342217ノート

反応式

HRID 342217 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][C:14]([O:18]C)=[CH:15][CH:16]=3)[CH:11]=[CH:10][N:9]=2)=[CH:4][CH:3]=1.C(OCC)(=O)C>C(O)(=O)C.Br>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=3)[CH:11]=[CH:10][N:9]=2)=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 8857Ethyl AcetateHCID 111415351-(4-Bromo-phenyl)-6-methoxy-isoquinoline

生成物 1

HCID 1361286691-(4-Bromo-phenyl)-isoquinolin-6-ol

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 260Hydrogen Bromide溶媒

実験手順

The 1-(4-bromo-phenyl)-6-methoxy-isoquinoline obtained is boiled under reflux in 53 ml of acetic acid and 37 ml of 62% aqueous hydrobromic acid. Subsequently, after cooling to room temperature and addition of 150 ml of ethyl acetate the separated precipitate is filtered off. The crystals are washed with ethyl acetate and dried. There are obtained 7.6 g of 1-(4-bromo-phenyl)-isoquinolin-6-ol, MS: m/e 300 (M+H+, 1 Br).

後処理

  1. filtrationis filtered off
  2. washThe crystals are washed with ethyl acetate
  3. customdried

出典と根拠

ORDレコード
ord-86d1d6104c494dc4936bdd7625021dfe
出典データセット
uspto-grants-1999_01
特許番号
US05856503

反応ノート

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