Iodoacetic Acid → 2-benzoylsulfanylacetic Acid

HRID 342331

反応式

HRID 342331 の反応式
[C:1]([OH:9])(=[S:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].I[CH2:13][C:14]([OH:16])=[O:15]>C(O)C.O>[C:1]([S:8][CH2:13][C:14]([OH:16])=[O:15])(=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

6

反応物 3

HCID 5240Iodoacetic AcidHCID 14797Potassium HydroxideHCID 178526132HCID 178526132、化合物

生成物 1

HCID 51165332-benzoylsulfanylacetic Acid収率 99%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒3 回HCID 962Water溶媒

実験手順

To a purged stirring solution at 0° C. of (5.74 g, 41.6 mmoles) thiobenzoic acid in (100 mL) ethanol was added (27.8 mL, 3N, 83.2 mmoles) potassium hydroxide followed by (7.70 g, 41.6 mmoles) iodoacetic acid in (30 mL) ethanol. The solution stirred for 10 hours at room temperature under argon. The ethanol was rotavapped and the orange solid product was dissolved in (40 mL) water. The solution was acidified to pH 2.0 where an orange precipitate formed. This was filtered, washed with water, and dried in vacuo to give (7.98 g, 99% yield) benzoylmercaptoacetic acid.

後処理

  1. customformed
  2. filtrationThis was filtered
  3. washwashed with water
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-3e014ac0b5e042538bd993422686bacb
出典データセット
uspto-grants-1999_01
特許番号
US05858327

関連ノート

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