Diisopropylethylamine → HCID 178463473、化合物

HRID 34241ノート

反応式

HRID 34241 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[C:12](O)=[O:13])[N:8]=[CH:7][N:6]=[C:5]2[NH:15][CH:16]([C:18]1[NH:22][C:21]2[CH:23]=[CH:24][C:25]([Cl:27])=[CH:26][C:20]=2[N:19]=1)[CH3:17].FC1C(OC(N(C)C)=[N+](C)C)=C(F)C(F)=C(F)C=1F.F[P-](F)(F)(F)(F)F.C(N(C(C)C)CC)(C)C.[CH3:63][N:64]1[CH2:69][CH2:68][N:67]([CH2:70][CH:71]2[CH2:76][CH2:75][CH2:74][CH2:73][NH:72]2)[CH2:66][CH2:65]1>CS(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[C:12]([N:72]1[CH2:73][CH2:74][CH2:75][CH2:76][CH:71]1[CH2:70][N:67]1[CH2:68][CH2:69][N:64]([CH3:63])[CH2:65][CH2:66]1)=[O:13])[N:8]=[CH:7][N:6]=[C:5]2[NH:15][CH:16]([C:18]1[NH:22][C:21]2[CH:23]=[CH:24][C:25]([Cl:27])=[CH:26][C:20]=2[N:19]=1)[CH3:17]

参加物

6

反応物 4

HCID 81531DiisopropylethylamineHCID 52568962-(4-Methyl-piperazin-1-ylmethyl)-piperidineHCID 15840204Pentafluorphenol-tetramethyluronium hexafluorophosphatHCID 1784635046-chloro-4-(1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline

生成物 1

HCID 178463473HCID 178463473、化合物

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

Prepared analogously to Example 37a from 6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline, pentafluorophenyl-tetramethyluronium-hexafluorophosphate (PFTU), diisopropylethylamine and 1-methyl-4-(piperidin-2-ylmethyl)-piperazine in DMSO at ambient temperature.

出典と根拠

ORDレコード
ord-8c3ed26bda1648a98069dd7d1f08ecad
出典データセット
uspto-grants-2008_09
特許番号
US07429597B2

反応ノート

読み込み中…