Water → pentan-3-one O-(2-nitrophenyl)oxime

HRID 342410

反応式

HRID 342410 の反応式
[CH3:1][CH2:2][C:3](=[N:6][OH:7])[CH2:4][CH3:5].[H-].[Na+].F[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[N+:17]([O-:19])=[O:18].O>CN(C)C=O>[N+:17]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[O:7][N:6]=[C:3]([CH2:4][CH3:5])[CH2:2][CH3:1])([O-:19])=[O:18]

参加物

6

反応物 4

HCID 962WaterHCID 24758Sodium hydrideHCID 738951-Fluoro-2-nitrobenzeneHCID 28017453-Pentanone oxime

生成物 1

HCID 53768417pentan-3-one O-(2-nitrophenyl)oxime収率 111.6%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

To a solution of pentan-3-one oxime (6.00 g) in dimethylformamide (30 ml) was added sodium hydride (60% oil suspension, 2.37 g) under ice cooling. After 15 minutes, to the above mixture was added dropwise 1-fluoro-2-nitrobenzene (5.98 g) in dimethylformamide (30 ml). The mixture was stirred for 3 hours at ambient temperature and poured into a mixture of ice and water. The separated oil was extracted with diethyl ether. The organic layer was washed with water, dried over sodium sulfate and evaporated in vacuo to give pentan-3-one O-(2-nitrophenyl)oxime (10.51 g) as a brown oil.

後処理

  1. extractionThe separated oil was extracted with diethyl ether
  2. washThe organic layer was washed with water
  3. dry with materialdried over sodium sulfate
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-639adc713648416286868651f74f44a8
出典データセット
uspto-grants-1999_01
特許番号
US05858995

関連ノート

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