Water → HCID 70197022、化合物

HRID 342427

反応式

HRID 342427 の反応式
[CH:1]([C:3]1[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[C:5]=2[O:6][C:7]=1[CH3:8])=[O:2].[BH4-].[Na+].O>CO>[OH:2][CH2:1][C:3]1[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[C:5]=2[O:6][C:7]=1[CH3:8]

参加物

5

反応物 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 867535523-Formyl-2-methyl-7-nitrobenzo[b]furan

生成物 1

HCID 70197022HCID 70197022、化合物収率 74.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 3-formyl-2-methyl-7-nitrobenzo[b]furan (1.83 g) and sodium borohydride (200 mg) in methanol (40 ml) was stirred at ambient temperature for 2 hours. The reaction mixture was poured into cold water. The separated oil was extracted with dichloromethane. The extract was washed with brine, dried and evaporated in vacuo. The residue was purified by column chromatography on silica gel to give 3-hydroxymethyl-2-methyl-7-nitrobenzo[b]furan (1.38 g) as a solid.

後処理

  1. extractionThe separated oil was extracted with dichloromethane
  2. washThe extract was washed with brine
  3. customdried
  4. customevaporated in vacuo
  5. customThe residue was purified by column chromatography on silica gel

出典と根拠

ORDレコード
ord-37724ab1656547ecbe4ee241eb8c5182
出典データセット
uspto-grants-1999_01
特許番号
US05858995

関連ノート

読み込み中…