Hydrochloric Acid → HCID 178436498、化合物

反応式

C1O[C:4]2([CH2:9][CH2:8][CH:7]([NH:10][C:11]3[C:16](Cl)=[C:15]([CH2:18][CH3:19])[N:14]=[CH:13][N:12]=3)[CH2:6][CH2:5]2)[O:3]C1.[ClH:21]>O1CCCC1.C1(C)C=CC=CC=1>[Cl:21][C:11]1([NH:10][CH:7]2[CH2:8][CH2:9][C:4](=[O:3])[CH2:5][CH2:6]2)[CH:16]=[C:15]([CH2:18][CH3:19])[N:14]=[CH:13][NH:12]1

参加物

実験手順

70 g (0.235 mol) of 4-(5-chloro-6-ethylpyrimidin-4-ylamino) cyclohexanone ethylene ketal (starting material for Example C) were stirred at 50° C. for 8 hours in a mixture of 250 ml of tetrahydrofuran and 250 ml of 2N hydrochloric acid. For work-up, the mixture was diluted with 250 ml of toluene, and the organic phase was extracted by stirring with sodium carbonate solution and water. Stripping off the solvent mixture gave 53.4 g (90% of theory) of product, which can be reacted without further purification.