Methyl chloroacetate → Methyl (4-methylpiperazin-1-yl)acetate
反応式
Cl[CH2:2][C:3]([O:5][CH3:6])=[O:4].[CH3:7][N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1>C(OCC)(=O)C>[CH3:7][N:8]1[CH2:13][CH2:12][N:11]([CH2:2][C:3]([O:5][CH3:6])=[O:4])[CH2:10][CH2:9]1参加物
4
実験手順
Methyl chloroacetate (8.8 ml., 0.10 mole) was added to a solution of N-methylpiperazine (24.4. ml., 0.22 mole) in ethyl acetate (140 ml.) and the mixture was stirred for 17 hours. The reaction mixture was filtered and the solvent was removed under vacuum. The resulting oil was dissolved in methylene chloride-methanol (9:1) and purified by flash chromatography (silica) to give 2-(4-methyl-1-piperazinyl)acetic acid, methyl ester as an oil (16.3 g, 95%).
後処理
- filtrationThe reaction mixture was filtered
- customthe solvent was removed under vacuum
- dissolutionThe resulting oil was dissolved in methylene chloride-methanol (9:1)
- custompurified by flash chromatography (silica)
出典と根拠
- ORDレコード
- ord-91b37a5954d74ff795689c1a0561d58a
- 出典データセット
- uspto-grants-1988_08
- 特許番号
- US04761415
反応ノート
読み込み中…