O-Cresol → HCID 54530810、化合物

HRID 342754

反応式

HRID 342754 の反応式
[C:1]1([CH3:8])[C:6]([OH:7])=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:9]([OH:22])(=O)[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=O>>[OH:7][C:6]1[CH:5]=[CH:4][C:3]([CH2:3][CH2:4][CH2:5][CH2:6][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][C:12]2[CH:11]=[CH:10][C:9]([OH:22])=[C:1]([CH3:8])[CH:2]=2)=[CH:2][C:1]=1[CH3:8].[OH:7][C:6]1[CH:5]=[CH:4][C:3]([C:18](=[O:20])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][C:9]([C:3]2[CH:4]=[CH:5][C:6]([OH:7])=[C:1]([CH3:8])[CH:2]=2)=[O:22])=[CH:2][C:1]=1[CH3:8]

参加物

4

反応物 2

HCID 335O-CresolHCID 5192Sebacic Acid

生成物 2

HCID 54530810HCID 54530810、化合物HCID 545710481,10-Bis(4-hydroxy-3-methylphenyl)decane-1,10-dione

反応条件

温度
80 °C

実験手順

This was prepared by the method reported by Schlack and Koller in Aromatic aliphatic diketones. P Schlack and W Koller. Ger. 1,086,711 Aug. 11, 1960. The title compound was prepare by treatment of orthocresol (2.2 moles) with sebacic acid (1 mole) in the presence of polyphosphoric acid (3 moles). The mixture was stirred for 4 hrs at 80° C. and poured to ice-water after cooling. The precipitant was filtered, dissolved in ethyl acetate and washed with water three times. The solvent was evaporated to yield a crude 1,10-bis(4-hydroxy-3-methylphenyl)decane-1,10-dione which was then subjected to Clemmensen reduction to give the title compound.

後処理

  1. customThis was prepared by the method
  2. temperatureafter cooling
  3. filtrationThe precipitant was filtered
  4. dissolutiondissolved in ethyl acetate
  5. washwashed with water three times
  6. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-116a6e421b2e46a3bc83e2cbd8661c88
出典データセット
uspto-grants-1999_01
特許番号
US05859067

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