Glycine → N-[(allyloxy)carbonyl]glycine

HRID 34279

反応式

HRID 34279 の反応式
[CH2:1]([O:4][C:5](Cl)=[O:6])[CH:2]=[CH2:3].[NH2:8][CH2:9][C:10]([OH:12])=[O:11]>O.[OH-].[Na+]>[CH2:1]([O:4][C:5]([NH:8][CH2:9][C:10]([OH:12])=[O:11])=[O:6])[CH:2]=[CH2:3]

参加物

5

反応物 2

HCID 750GlycineHCID 18052Allyl chloroformate

生成物 1

HCID 11964402N-[(allyloxy)carbonyl]glycine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

At 0°, 12 ml of chloroformic acid allyl ester are added dropwise to a solution of 7.51 g of glycine in 20 ml of water and 44 ml of 5N NaOH solution. The suspension is then stirred for 16 hours at room temperature. After removing the insoluble material by filtration, the filtrate is diluted with 100 ml of water and washed twice with CH2Cl2. The aqueous phase is adjusted to pH 2 with 4N HCl and extracted twice with CH2Cl2. The combined organic extracts are washed once with brine, dried over MgSO4 and concentrated by evaporation to form the white crystals of the title compound.

後処理

  1. customAfter removing the insoluble material
  2. filtrationby filtration
  3. additionthe filtrate is diluted with 100 ml of water
  4. washwashed twice with CH2Cl2
  5. extractionextracted twice with CH2Cl2
  6. washThe combined organic extracts are washed once with brine
  7. dry with materialdried over MgSO4
  8. concentrationconcentrated by evaporation

出典と根拠

ORDレコード
ord-9a103a7e86b8409ea9662cee16a2dda8
出典データセット
uspto-grants-1988_08
特許番号
US04761408

関連ノート

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