Ethanol → Ethyl 2-Aminobutyrate Hydrochloride

HRID 342864

反応式

HRID 342864 の反応式
S(Cl)([Cl:3])=O.[NH2:5][CH:6]([CH2:10][CH3:11])[C:7]([OH:9])=[O:8].[CH2:12](O)[CH3:13]>>[ClH:3].[NH2:5][CH:6]([CH2:10][CH3:11])[C:7]([O:9][CH2:12][CH3:13])=[O:8]

参加物

4

反応物 3

HCID 702EthanolHCID 6657Alpha-Aminobutyric AcidHCID 24386Thionyl Chloride

生成物 1

HCID 12844023Ethyl 2-Aminobutyrate Hydrochloride収率 97%

反応条件

温度
27 °C

実験手順

Thionyl chloride (1.25 moles) was added to a solution of 2-aminobutyric acid (1 mole) in SD12A3 (95% ethanol/5% toluene) at a temperature of <5° C. When addition was complete, the mixture was stirred at 27° C. for 16 hours and the resulting precipitate filtered off and washed with methyl t-butyl ether to give the desired product as a white solid (97% yield).

後処理

  1. additionWhen addition
  2. filtrationthe resulting precipitate filtered off
  3. washwashed with methyl t-butyl ether

出典と根拠

ORDレコード
ord-57d667095fe445b4895e42c5c900e60d
出典データセット
uspto-grants-1999_01
特許番号
US05859240

関連ノート

読み込み中…