Chlorosulfonic acid → (R)-2-Butyl-2-ethylaziridine

HRID 342869ノート

反応式

HRID 342869 の反応式
ClS(O)(=O)=O.[CH2:6]([C:10]1([CH2:13][CH3:14])[CH2:12][NH:11]1)[CH2:7][CH2:8][CH3:9]>ClC(Cl)C>[CH2:6]([C@:10]1([CH2:13][CH3:14])[CH2:12][NH:11]1)[CH2:7][CH2:8][CH3:9]

参加物

4

反応物 2

HCID 24638Chlorosulfonic acidHCID 217099702-Butyl-2-ethylaziridine

生成物 1

HCID 53812986(R)-2-Butyl-2-ethylaziridine収率 77%

試薬・触媒・溶媒 1

HCID 63651,1-Dichloroethane溶媒

実験手順

Chlorosulphonic acid (1 molar equivalent) was added to a solution of the product from step (f) (15 g) in dichloroethane (90 ml) at a temperature of <16° C. When addition was complete, the mixture was stirred for 2 hours at room temperature and then evaporated in vacuo. Water (60 ml) and 5% w/v aqu. NaOH (41 ml) were added and the mixture distilled at atmospheric pressure. The organic phase of the distillate was separated and dried over KOH to give a solution of the desired product (77% yield).

後処理

  1. additionWhen addition
  2. customevaporated in vacuo
  3. additionNaOH (41 ml) were added
  4. distillationthe mixture distilled at atmospheric pressure
  5. customThe organic phase of the distillate was separated
  6. dry with materialdried over KOH

出典と根拠

ORDレコード
ord-bcd591f56ef74c39a95b82a1fd46c7ab
出典データセット
uspto-grants-1999_01
特許番号
US05859240

反応ノート

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