Sodium Hydroxide → 3-H-epoxybenzazepin
反応式
C(O)(=O)C(O)=O.[O:7]1[CH:12]2[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH:8]1[CH2:9][NH:10][CH2:11]2.[OH-].[Na+]>>[N:10]1[C:9]2[CH:8]=[CH:14][CH:15]=[CH:16][C:17]=2[CH:18]=[CH:13][CH:12]2[O:7][C:11]=12参加物
3
実験手順
The product prepared in Example 19 (3.85 g, 0.15M) was made basic with NaOH, partitioned between H2O and CH2Cl2, and the organic layer dried (Na2SO4) and evaporated to give the 3-H-epoxybenzazepin (2.50 g, 0.015M). This compound was treated with propionic anhydride (10 ml) and allowed to stir for two hours. Excess propionic anhydride was removed in vacuo to give 3-propoxy-epoxybenzazepin as a white solid (3.3 g, 98% yield).
後処理
- custompartitioned between H2O and CH2Cl2
- dry with materialthe organic layer dried (Na2SO4)
- customevaporated
出典と根拠
- ORDレコード
- ord-d42e5e901cc24ff1b3faeecc272967cc
- 出典データセット
- uspto-grants-1988_08
- 特許番号
- US04761413
反応ノート
読み込み中…