Imidazole → (1H-Imidazol-1-yl)(1-methylcyclopropyl)methanone
反応式
[CH3:1][C:2]1([C:5](Cl)=[O:6])[CH2:4][CH2:3]1.[NH:8]1[CH:12]=[CH:11][N:10]=[CH:9]1>C1(C)C=CC=CC=1.O1CCCC1>[CH3:1][C:2]1([C:5]([N:8]2[CH:12]=[CH:11][N:10]=[CH:9]2)=[O:6])[CH2:4][CH2:3]1参加物
5
実験手順
A solution of 1-methylcyclopropylcarbonyl chloride (11.8 g) in toluene (15 ml) was added dropwise to a solution of imidazole (13.6 g) in tetrahydrofuran (100 ml) whilst maintaining the temperature below 25° C. The mixture was stirred for 3 hours and filtered. The filtrate was evaporated to dryness to give 1-(1-methylcyclopropylcarbonyl)-imidazole (13.6 g) as a white solid, mp 34°-35° C.
後処理
- temperaturewhilst maintaining the temperature below 25° C
- filtrationfiltered
- customThe filtrate was evaporated to dryness
出典と根拠
- ORDレコード
- ord-591f051850c14bdbb0fa18c652bacb2d
- 出典データセット
- uspto-grants-1999_01
- 特許番号
- US05859283
反応ノート
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