2-Aminopropanol → 2-(N-Hexadecanoyl)amino-1-propanol

HRID 34304

反応式

HRID 34304 の反応式
[CH3:1][CH:2]([NH2:5])[CH2:3][OH:4].[C:6](Cl)(=[O:22])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]>C(Cl)Cl>[C:6]([NH:5][CH:2]([CH3:1])[CH2:3][OH:4])(=[O:22])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]

参加物

4

反応物 2

HCID 51262-AminopropanolHCID 8206Palmitoyl chloride

生成物 1

HCID 184318022-(N-Hexadecanoyl)amino-1-propanol収率 51%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 4.00 g (53.2 mmol) of commercially obtained dl-2-amino-1-propanol b and 8.0 g (8.8 ml, 29.3 mmol) of hexadecanoyl chloride in 100 ml of CH2Cl2 was stirred at room temperature for hours. The solution was concentrated and the residue was boiled with 200 ml acetone and decanted. The solution was concentrated and the residue was chromatographed on silica gel using 50% ethylacetate in hexane to afford 4.15 g (51%) of the title compound as white needles, m.p. 75-76° C. Using the same procedure as in Example 19, the following compounds were prepared:

後処理

  1. concentrationThe solution was concentrated
  2. customdecanted
  3. concentrationThe solution was concentrated
  4. customthe residue was chromatographed on silica gel using 50% ethylacetate in hexane

出典と根拠

ORDレコード
ord-9fed08b7a87d4dc89a917158d7429c2c
出典データセット
uspto-grants-1988_08
特許番号
US04761404

関連ノート

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