2-Phenylacetophenone → 1,2-Diphenyl-1-ethanone oxime

HRID 343089

反応式

HRID 343089 の反応式
[C:1]1([C:7]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:17][OH:18].O.O.O.C([O-])(=O)C.[Na+]>C(O)C.O>[C:1]1([C:7](=[N:17][OH:18])[CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

6

反応物 3

HCID 99482-PhenylacetophenoneHCID 443297Hydroxyamine hydrochlorideHCID 23665404Sodium Acetate Trihydrate

生成物 1

HCID 2353831,2-Diphenyl-1-ethanone oxime収率 95%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒2 回HCID 962Water溶媒

実験手順

A solution of deoxybenzoin (407.4 g, 2.076 mol) in 2 L of absolute ethanol and 600 mL of water was treated with hydroxylamine hydrochloride (288 g, 4.15 mol) and sodium acetate trihydrate (564 g, 4.15 mol). The solution was then warmed to reflux for 2 hours. The reaction mixture was then diluted with 1000 mL of 30% aqueous ethanol and allowed to cool to room temperature whereupon crystals of pure oxime formed which were isolated by filtration and air dried to afford 415.4 g, 95%, mp 94°-96° C. of pure deoxybenzoin oxime.

後処理

  1. temperatureThe solution was then warmed
  2. temperatureto reflux for 2 hours
  3. customformed which
  4. customwere isolated by filtration and air
  5. customdried

出典と根拠

ORDレコード
ord-bd13a5f5f72e4db9ba33ba95fdd8b9fb
出典データセット
uspto-grants-1999_01
特許番号
US05859257

関連ノート

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