Methanol → HCID 13744932、化合物

HRID 34325ノート

反応式

HRID 34325 の反応式
Cl[C:2]1[C:11]([C:12]([O:14][CH2:15]C)=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][C:6]([S:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=3)=[CH:7][CH:8]=2)[N:3]=1.[Na].[CH3:28][OH:29]>C(Cl)Cl>[CH3:28][O:29][C:2]1[C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][C:6]([S:17][CH2:18][C:19]3[CH:20]=[CH:21][C:22]([O:25][CH3:26])=[CH:23][CH:24]=3)=[CH:7][CH:8]=2)[N:3]=1

参加物

5

反応物 3

HCID 887MethanolHCID 5360545SodiumHCID 13744931Ethyl 2-chloro-7-(4-methoxyphenylmethylthio)quinolin-3-carboxylate

生成物 1

HCID 13744932HCID 13744932、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The ester from Step 3 (7.76 g) was added to a solution of sodium (920 mg) in anhydrous methanol (50 ml) and the resulting suspension was refluxed under an argon atmosphere for 75 minutes. The mixture was cooled, diluted with CH2Cl2 (200 ml), washed with water (3×50 ml) and reduced to dryness to provide the title compound, m.p. 133°-134.5°.

後処理

  1. temperaturethe resulting suspension was refluxed under an argon atmosphere for 75 minutes
  2. temperatureThe mixture was cooled
  3. washwashed with water (3×50 ml)

出典と根拠

ORDレコード
ord-9b4fcb92c3a540a2a1e2a1fe20f8ad8a
出典データセット
uspto-grants-1988_08
特許番号
US04761425

反応ノート

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