Potassium Carbonate → HCID 57217469、化合物

HRID 343289ノート

反応式

HRID 343289 の反応式
Cl.[C:2]([NH2:5])(=[NH:4])[CH3:3].C(=O)([O-])[O-].[K+].[K+].Cl[CH:13]([C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=1)[C:14](Cl)=[O:15]>O1CCCC1>[CH3:24][O:23][C:20]1[CH:21]=[CH:22][C:17]([C:13]2[C:14](=[O:15])[N:5]=[C:2]([CH3:3])[N:4]=2)=[CH:18][CH:19]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 67170Acetamidine monohydrochlorideHCID 15166130HCID 15166130、化合物

生成物 1

HCID 57217469HCID 57217469、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
15 °C

実験手順

A stirred mixture of 11.8 grams (0.10 mole) of acetamidine hydrochloride in 200 mL of tetrahydrofuran is cooled to about 15° C., and 41.8 grams (0.30 mole) of potassium carbonate is added portionwise. To this is then added portionwise 21.8 grams (0.10 mole) of 2-chloro-2-(4-methoxyphenyl)acetyl chloride. Upon completion of addition, the reaction mixture is stirred for 15 minutes at 15° C., then it is warmed to reflux where it stirred for about four hours. The reaction mixture is then cooled and filtered to collect the by-product potassium chloride. The filtrate is concentrated under reduced pressure, yielding 4-(4-methoxyphenyl)-2-methylimidazol-5-one.

後処理

  1. additionUpon completion of addition
  2. temperatureit is warmed
  3. temperatureto reflux where it
  4. stirringstirred for about four hours
  5. temperatureThe reaction mixture is then cooled
  6. filtrationfiltered
  7. customto collect the by-product potassium chloride
  8. concentrationThe filtrate is concentrated under reduced pressure

出典と根拠

ORDレコード
ord-8d72585a46ed49ce8453f38a41e59c15
出典データセット
uspto-grants-1999_01
特許番号
US05861359

反応ノート

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