Benzyl Alcohol → Benzyl 3-bromopropanoate

HRID 343463ノート

反応式

HRID 343463 の反応式
O.[C:2]1([CH3:12])[CH:7]=[CH:6][C:5](S(O)(=O)=O)=[CH:4][CH:3]=1.[Br:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17].C(O)C1C=CC=CC=1>C1C=CC=CC=1>[CH2:12]([O:18][C:16](=[O:17])[CH2:15][CH2:14][Br:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 244Benzyl AlcoholHCID 115533-Bromopropionic acidHCID 521998p-Toluenesulfonic acid monohydrate

生成物 1

HCID 252570Benzyl 3-bromopropanoate収率 56%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A spatula tip full of p-toluenesulfonic acid monohydrate was added to a solution of 3-bromopropionic acid (20.49 g, 0.134 mol) and benzyl alcohol (15 mL, ~15.7 g, 0.145 mol) in benzene (150 mL). A Dean-Stark trap was fitted to the reaction vessel and the solution was held at reflux with overnight stirring. After 16 hr at reflux, the reaction was cooled, washed with saturated sodium bicarbonate, dried (Na2SO4), and concentrated to an oil (28.78 g). Fractional distillation at reduced pressure (0.18 torr) gave the desired product as a colorless liquid (18.49 g, 56%) boiling in the range 99°-109° C.

後処理

  1. customA Dean-Stark trap was fitted to the reaction vessel
  2. temperatureat reflux with overnight
  3. temperatureAfter 16 hr at reflux
  4. temperaturethe reaction was cooled
  5. washwashed with saturated sodium bicarbonate
  6. dry with materialdried (Na2SO4)
  7. concentrationconcentrated to an oil (28.78 g)
  8. distillationFractional distillation at reduced pressure (0.18 torr)

出典と根拠

ORDレコード
ord-c7e51193a5394d8895bd4e787eef79d9
出典データセット
uspto-grants-1999_01
特許番号
US05861428

反応ノート

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