Hydrochloric Acid → 2-(3-Hydroxypropyl)-6-methylphenol

HRID 343483ノート

反応式

HRID 343483 の反応式
[CH2:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:5]=1[OH:11])[CH:2]=[CH2:3].[OH-:12].[Na+].OO.Cl>>[OH:12][CH2:3][CH2:2][CH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:5]=1[OH:11]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 768832-Allyl-6-methylphenol

生成物 1

HCID 543527972-(3-Hydroxypropyl)-6-methylphenol

実験手順

To a borane-tetrahydrofuran complex solution (100 mL, 1M solution) was added dropwise 2-allyl-6-methylphenol (21 g) under ice-cooling. After stirring at room temperature for 3 hours, a 2N aqueous sodium hydroxide solution (55 mL) and a 30% aqueous hydrogen peroxide solution (12 mL) were added to the reaction mixture under ice-cooling. After stirring overnight at room temperature, the reaction mixture was acidified with a 2N hydrochloric acid and extracted with diethyl ether. The organic layer was washed with brine, dried over magnesium sulfate, filtered and evaporated. The residue was purified by silica gel column chromatography and dried to give the title compound (15 g).

後処理

  1. temperaturecooling
  2. temperaturecooling
  3. stirringAfter stirring overnight at room temperature
  4. extractionextracted with diethyl ether
  5. washThe organic layer was washed with brine
  6. dry with materialdried over magnesium sulfate
  7. filtrationfiltered
  8. customevaporated
  9. customThe residue was purified by silica gel column chromatography
  10. customdried

出典と根拠

ORDレコード
ord-1f60246f1d7945c9b02b09dcabb2bf5c
出典データセット
uspto-grants-1999_01
特許番号
US05861437

反応ノート

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