Lithium Hydroxide → HCID 178489168、化合物

HRID 343530ノート

反応式

HRID 343530 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[NH:17][N:16]=[N:15][N:14]=2)=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[Li+].O1CCCC1.O>Cl.ClCCl>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[NH:14][N:15]=[N:16][N:17]=2)=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

参加物

6

反応物 3

HCID 3939Lithium HydroxideHCID 21881883Oxolane--water (1/1)HCID 178497409HCID 178497409、化合物

生成物 1

HCID 178489168HCID 178489168、化合物

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 6344Dichloromethane溶媒

実験手順

Combine methyl 2-methoxy-5-(1H-tetrazol-5-yl)benzoate (1 mmol) and lithium hydroxide (1.1 mmol) in 1/1 tetrahydrofuran/water (5 mL). After 24 hours, dilute the reaction mixture with a 0.5M aqueous hydrochloric acid solution and dichloromethane. Separate the layers and extract the aqueous layer three times with dichloromethane. Combine the organic layers, dry over MgSO4, filter, and evaporate in vacuo to give the title compound.

後処理

  1. customSeparate the layers
  2. extractionextract the aqueous layer three times with dichloromethane
  3. dry with materialdry over MgSO4
  4. filtrationfilter
  5. customevaporate in vacuo

出典と根拠

ORDレコード
ord-c1672ff1b1dd487cb2c1ae949aefbe18
出典データセット
uspto-grants-1999_01
特許番号
US05861417

反応ノート

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