Triethylamine → 3-(2,6-Diisopropylphenyl)-1-methyl-2-thioxo-imidazolidin-4-one

HRID 343595

反応式

HRID 343595 の反応式
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]([CH3:12])[CH3:11])[C:5]=1[N:13]=[C:14]=[S:15])([CH3:3])[CH3:2].Cl.C([O:19][C:20](=O)[CH2:21][NH:22][CH3:23])C.C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]([CH3:11])[CH3:12])[C:5]=1[N:13]1[C:20](=[O:19])[CH2:21][N:22]([CH3:23])[C:14]1=[S:15])([CH3:2])[CH3:3]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 1411942-Isothiocyanato-1,3-bis(propan-2-yl)benzeneHCID 171173Ethyl N-methylaminoacetate hydrochloride

生成物 1

HCID 857014683-(2,6-Diisopropylphenyl)-1-methyl-2-thioxo-imidazolidin-4-one収率 60.2%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

The title compound was prepared by the procedure described in Example 1 using 8.3 g of 2,6-diisopropylphenyl-isothiocyanate, 5.8 g of sarcosine ethyl ester hydrochloride, 14.5 g of triethyl amine, and 200 mL of chloroform. Crystallization from diethyl ether/hexane mixture afforded the title compound (6.6 g) as a tan solid, m.p. 174°-176° C. Anal. Calcd. for C16H22N2OS: C, 66.17; H, 7.63; N, 9.64. Found: C, 66.39; H, 7.63; N, 9.59. Mass spectrum (+FAB, [M+H]+) m/z 269/271.

後処理

  1. customThe title compound was prepared by the procedure
  2. customCrystallization from diethyl ether/hexane mixture

出典と根拠

ORDレコード
ord-41693961050241339f4fa0e3f228e058
出典データセット
uspto-grants-1999_01
特許番号
US05861517

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