Triethylamine → 3-(2,5-Dimethylphenyl)-1-ethyl-2-thioxo-imidazolidin-4-one

HRID 343607

反応式

HRID 343607 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[N:9]=[C:10]=[S:11].[CH2:12]([NH:14][CH2:15][C:16](O)=[O:17])[CH3:13].C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[N:9]1[C:16](=[O:17])[CH2:15][N:14]([CH2:12][CH3:13])[C:10]1=[S:11]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 1404992,5-Dimethylphenyl isothiocyanateHCID 316542N-Ethylglycine

生成物 1

HCID 118175103-(2,5-Dimethylphenyl)-1-ethyl-2-thioxo-imidazolidin-4-one収率 42.7%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

The title compound was prepared by the procedure described in Example 9 using 16.3 g of 2,5-dimethylphenyl-isothiocyanate, 18.4 g of N-ethyl glycine, 20.2 g of triethyl amine, and 250 mL of chloroform. Crystallization from ethyl acetate afforded the title compound (10.6 g) as an off-white solid, m.p. 176°-178° C. Anal. Calcd. for. C13H16N2OS: C, 62.87; H, 6.49; N, 11.28. Found: C, 62.70; H, 6.46; N, 11.27. Mass spectrum (EI, M.+) m/z 248.

後処理

  1. customThe title compound was prepared by the procedure
  2. customCrystallization from ethyl acetate

出典と根拠

ORDレコード
ord-fbbdbce8eb584f1faae36ae160e84bd0
出典データセット
uspto-grants-1999_01
特許番号
US05861517

関連ノート

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