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Triethylamine → 3-(Indan-5-yl)-1-isopropyl-2-thioxo-imidazolidin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | NoName_76 | HCID 414244 | — |
| 反応物 | 5-isothiocyanato-2,3-dihydro-1H-indene | HCID 2759357 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 3-(Indan-5-yl)-1-isopropyl-2-thioxo-imidazolidin-4-one | HCID 15389491 | 36.1% |
反応手順
The title compound was prepared by the procedure described in Example 18 using 17.5 g of indan-5-yl-isothiocyanate, 21.2 g of N-isopropyl glycine, 21.0 g of triethyl amine, and 300 mL of chloroform. Crystallization from ethanol afforded the title compound (9.9 g) as a white solid, m.p. 178°-180° C. Anal. Calcd. for. C15H18N2OS: C, 56.66; H, 6.61; N, 10.21. Found: C, 56.70; H, 6.67; N, 10.22. Mass spectrum (EI, M.+) m/z 274.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05861517 |
| 出典データセット | uspto-grants-1999_01 |
| ORD ID | ord-bbdf46dbe9fe4895bc580feea3cdef89 |
| 出典メモ | uspto-grants-1999_01 |