Ethanol → 3-(4-Phenylphenoxy)-1-propanol

HRID 343636ノート

反応式

HRID 343636 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.C(O)C.Br[CH2:18][CH2:19][CH2:20][OH:21].[OH-].[Na+]>O>[OH:21][CH2:20][CH2:19][CH2:18][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 702EthanolHCID 71034-HydroxybiphenylHCID 123083-Bromo-1-propanolHCID 14798Sodium Hydroxide2 回

生成物 1

HCID 283517393-(4-Phenylphenoxy)-1-propanol収率 43%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Into a 200 ml flask, 7.82 g (41.1 mmol) of 4-hydroxybiphenyl, 83 ml of ethanol, 6 g (43.2 mmol) of 3-bromo-1-propanol and a NaOH aqueous solution (1.73 g (43.2 mmol) of NaOH/6 ml of water) were sequentially added, and the mixture was heated and refluxed for 6.5 hours. To the reaction solution, 50 ml of water was added, whereupon precipitated crystals were collected by filtration and recrystallized from ethanol to obtain 4.0 g (yield: 43%) of 4-(3-hydroxypropoxy)biphenyl (1) as a colorless powder.

後処理

  1. temperaturethe mixture was heated
  2. temperaturerefluxed for 6.5 hours
  3. customwhereupon precipitated crystals
  4. filtrationwere collected by filtration
  5. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-9e0ab87c47fd417cb1c3eb6c78e3154c
出典データセット
uspto-grants-1999_01
特許番号
US05861534

反応ノート

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